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Efficacy of Chinese Medicinal Formulae for Antimicrobial-resistant Pneumonia: A Systematic Review and Meta-analysis / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 205-212, 2021.
Article in Chinese | WPRIM | ID: wpr-906442
ABSTRACT

Objective:

To evaluate the efficacy and safety of Chinese medicinal formulae in the treatment of antimicrobial-resistant pneumonia.

Method:

Following article retrieval from eight databases and data extraction by two reviewers, the methodological quality of the included trials was assessed and the outcome indicators were subjected to Meta-analysis using RevMan 5.3.

Result:

A total of 24 randomized controlled trials (RCTs) were included, involving 1 818 cases. Meta-analysis showed that Chinese medicinal formulae combined with western routine intervention was superior to the western routine intervention in improving the overall response rate (ORR) [relative risk (RR)=1.27, 95% confidence interval (CI) (1.21, 1.34), <inline-formula><alternatives><mmlmath xmlnsmml="http//www.w3.org/1998/Math/MathML" id="M5"><mmlmi>P</mmlmi></mmlmath><graphic specific-use="big" xmlnsxlink="http//www.w3.org/1999/xlink" xlinkhref="alternativeImage/27038DAF-2FF7-4d58-8001-0E6465A33408-M005.jpg"><?fx-imagestate width="2.28600001" height="2.62466669"?></graphic><graphic specific-use="small" xmlnsxlink="http//www.w3.org/1999/xlink" xlinkhref="alternativeImage/27038DAF-2FF7-4d58-8001-0E6465A33408-M005c.jpg"><?fx-imagestate width="2.28600001" height="2.62466669"?></graphic></alternatives></inline-formula><0.000 01], the bacterial clearance rate [RR=1.49,95% CI (1.33, 1.66), <inline-formula><alternatives><mmlmath xmlnsmml="http//www.w3.org/1998/Math/MathML" id="M6"><mmlmi>P</mmlmi></mmlmath><graphic specific-use="big" xmlnsxlink="http//www.w3.org/1999/xlink" xlinkhref="alternativeImage/27038DAF-2FF7-4d58-8001-0E6465A33408-M006.jpg"><?fx-imagestate width="2.28600001" height="2.62466669"?></graphic><graphic specific-use="small" xmlnsxlink="http//www.w3.org/1999/xlink" xlinkhref="alternativeImage/27038DAF-2FF7-4d58-8001-0E6465A33408-M006c.jpg"><?fx-imagestate width="2.28600001" height="2.62466669"?></graphic></alternatives></inline-formula><0.000 01], and the clinical pulmonary infection score (CPIS) [mean difference (MD)=-1.64, 95% CI (-1.87, -1.41), <inline-formula><alternatives><mmlmath xmlnsmml="http//www.w3.org/1998/Math/MathML" id="M7"><mmlmi>P</mmlmi></mmlmath><graphic specific-use="big" xmlnsxlink="http//www.w3.org/1999/xlink" xlinkhref="alternativeImage/27038DAF-2FF7-4d58-8001-0E6465A33408-M007.jpg"><?fx-imagestate width="2.28600001" height="2.62466669"?></graphic><graphic specific-use="small" xmlnsxlink="http//www.w3.org/1999/xlink" xlinkhref="alternativeImage/27038DAF-2FF7-4d58-8001-0E6465A33408-M007c.jpg"><?fx-imagestate width="2.28600001" height="2.62466669"?></graphic></alternatives></inline-formula><0.000 01]. There was no significant difference in the incidence of adverse reactions [RR=0.72, 95% CI (0.48, 1.07),<inline-formula><alternatives><mmlmath xmlnsmml="http//www.w3.org/1998/Math/MathML" id="M8"><mmlmtext> </mmlmtext><mmlmi>P</mmlmi></mmlmath><graphic specific-use="big" xmlnsxlink="http//www.w3.org/1999/xlink" xlinkhref="alternativeImage/27038DAF-2FF7-4d58-8001-0E6465A33408-M008.jpg"><?fx-imagestate width="3.04799986" height="2.62466669"?></graphic><graphic specific-use="small" xmlnsxlink="http//www.w3.org/1999/xlink" xlinkhref="alternativeImage/27038DAF-2FF7-4d58-8001-0E6465A33408-M008c.jpg"><?fx-imagestate width="3.04799986" height="2.62466669"?></graphic></alternatives></inline-formula>=0.1]. The comparison with the western routine intervention also revealed that Chinese medicinal formulae better improved the ORR and CPIS.

Conclusion:

According to the current research results, the Chinese medicinal formulae alone or combined with western routine intervention yielded more favorable clinical outcomes than western routine intervention in the treatment of antimicrobial-resistant pneumonia, without increasing the incidence of adverse events. Due to limited quality and quantity of the included RCTs, more high-quality trials are required to verify the above conclusions.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Etiology study / Systematic reviews Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Etiology study / Systematic reviews Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2021 Type: Article