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Research Progress of Traditional Chinese Medicine in Improving Pathogenesis of Depression / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 244-250, 2021.
Article in Chinese | WPRIM | ID: wpr-906477
ABSTRACT
Depression is a kind of psychoaffective disorder,which is mainly characterized by persistent depression and mood disorders. It is related to many factors such as abnormal expression of neurotransmitterssecretion of inflammatory cytokines,changes in neuronal pathways,persistent disorder of hypothalamus-pituitary-adrenal (HPA) axis,changes of intestinal flora environment,abnormal mitochondria structure,and many other factors,which cause serious damage to human health. At present,western medicine is mainly treated with antidepressant drugs in clinical practice,which can exert short-term efficacy,but long-term use will cause adverse side effects. Traditional Chinese medicine(TCM) emphasizes the holistic view of psychosomatic integration and has rich clinical practice experience,which gives it a certain therapeutic advantages in the prevention and treatment of depression. Moreover,modern research has shown that TCM has played an important role in the prevention and treatment of depression through its multi-target,multi-mechanism and multi-pathway mode of action. In recent years,the study on TCM in treating depression has been deepening,and more and more TCM and TCM compounds have been proved to be able to regulate and improve the pathogenesis of depression and play an antidepressant role. Therefore,this paper systematically sorted out the research literature on TCM in improving the pathogenesis of depression in the past 5 years,and summarized and elaborated these literature according to the following topics:TCM affects the expression of neurotransmitters and their receptors,improves the plasticity of nerve cells and related signaling pathways,regulates the secretion of inflammatory factors and improves the disorder of HPA axis, TCM regulats intestinal flora environment to relieve depression, TCM adjusts the mitochondrial function of TCM to relieve depression. The study found that most of the TCM exert the antidepressant effect mainly by affecting the expression of neurotransmitters and improving neural signaling pathways,while the research on Chinese medicinals regulating and improving the intestinal flora environment and mitochondrial function is relatively rare,which needs further research to provide reference for better exploration of depression in the future.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2021 Type: Article