Research Progress of Citri Reticulatae Semen / 中国实验方剂学杂志

ABSTRACT

Citri Reticulatae Semen is a traditional Chinese medicine in our country. By referring to the relevant literature and materials such as the works of ancient and modern materia medica， this paper summarizes the historical evolution of processing， quality analysis， pharmacological effects and other aspects of Citri Reticulatae Semen. The results showed that the processing methods of Citri Reticulatae Semen in the past dynasties mainly included stir-frying， processing with wine， baking with wine， etc. The modern stir-baking with salt solution was developed on the basis of the ancient stir-frying with green salt， most of the national and provincial processing standards contained crude and salt-processed products of Citri Reticulatae Semen. The properties and flavors of Citri Reticulatae Semen in the past dynasties were basically consistent with those in modern times. It is bitter in taste and neutral in nature. It belongs to the liver and kidney meridians and has the effects of regulating Qi， dispersing knots and relieving pain. Citri Reticulatae Semen contains limonins， fatty acids， proteins and mineral elements， etc. High performance liquid chromatography （HPLC）， gas chromatography-mass spectrometry （GC-MS） and thin layer chromatography （TLC） were commonly used to detect and analyze Citri Reticulatae Semen. Citri Reticulatae Semen has anti-tumor， anti-inflammatory， analgesic and antibacterial activities， and processing can change the content of its chemical components to a certain extent. In a word， the current research about Citri Reticulatae Semen is not enough in-depth， it is necessary to further analyze the material basis of efficacy of Citri Reticulatae Semen and its processed products， explore the change law of chemical components before and after processing and the relationship between chemical composition and activity， and clarify the processing mechanism for providing scientific basis for its standardized processing， quality control and clinical rational use.