Duration of Antimuscarinic Administration for Treatment of Overactive Bladder Before Which One Can Assess Efficacy: An Analysis of Predictive Factors / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: 171-177, 2015.
Article
in English
| WPRIM
| ID: wpr-90689
ABSTRACT
PURPOSE:
To determine the duration of antimuscarinic therapy for overactive bladder syndrome (OAB) appropriate for assessment of the efficacy of treatment, and to evaluate the possible predictive factors for response to therapy.METHODS:
All OAB patients who visited a urology outpatient clinic of a tertiary referral center and who were prescribed 5 mg of solifenacin or 4 mg of tolterodine extended release capsules daily were enrolled in the study. Patients were asked to continue therapy for 6 months. All enrolled patients completed the patient perception of bladder condition, overactive bladder symptom score (OABSS), and the modified Indevus Urgency Severity Scale questionnaires. All patients underwent uroflowmetry.RESULTS:
A total of 164 patients were enrolled and 125 patients (76%) had at least one follow-up visit. The mean follow-up interval was 1 month (range, 0.5-6 months). Sixty-two patients (49.6%; 95% confidence interval [CI], 40.7-58.5) responded to antimuscarinic treatment. The median time for the onset of response was 3 months (95% CI, 1-6). Multivariate Cox proportional-hazards model revealed that elevated baseline OABSS was an independent predictor of responsiveness to therapy. Receiver operating characteristic (ROC) curve analysis revealed an optimal OABSS cutoff value of > or =7, with an area under the ROC curve of 0.79 (95% CI, 0.70-0.88; sensitivity, 91.9%; specificity, 60.7%).CONCLUSIONS:
The median time for a therapeutic response was 3 months, and OABSS was the only predictor for responsiveness. These findings may serve as a guideline when prescribing antimuscarinic treatment for OAB patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urology
/
Urinary Bladder
/
Capsules
/
ROC Curve
/
Follow-Up Studies
/
Sensitivity and Specificity
/
Treatment Outcome
/
Cholinergic Antagonists
/
Urinary Bladder, Overactive
/
Tertiary Care Centers
Type of study:
Diagnostic study
/
Practice guideline
/
Observational study
/
Prognostic study
/
Qualitative research
/
Risk factors
Limits:
Humans
Language:
English
Journal:
International Neurourology Journal
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS