Progress of allogeneic hematopoietic stem cell transplantation for hyper IgM syndrome / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 386-390, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-907244
ABSTRACT
Hyper immunoglobulin M syndrome(HIGM)is a group of rare primary immunodeficiency disease(PID)caused by single gene mutation.Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is the only treatment to cure the disease, and patients should receive allo-HSCT if possible.Younger patients who can keep in good pre-transplant state, obtain matching sibling donor and tolerate to myeloablative conditioning may get better outcome after early transplantation, and the overall survival rate can reach 80%.The progress in the timing of transplantation, donor and graft, conditioning regimen, prevention and treatment of complications of allo-HSCT for HIGM is reviewed in this paper.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2021
Type:
Article
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