Progress on mycoplasma pneumoniae in the pathogenesis of asthma / 国际儿科学杂志

ABSTRACT

Mycoplasma pneumoniae(MP)infection and asthma are common respiratory diseases in children, and they are closely related.MP infection induces asthma attacks, and anti-MP infection treatment can help control the degree in children with asthma.This article describes the relationship between MP infection and asthma, and provides a theoretical basis for the treatment of asthma.MP infection can damage the airway and cause chronic cough and bronchial asthma attacks.MP infects the airway epithelium and secretes community-acquired respiratory distress syndrome toxin(CARDS Tx)combined with the airway mucosa to cause the airway epithelial damage, and promotes the body to form a TH2-mediated immune response, mediates the production of specific IgE, and then triggers the release of inflammatory mediators involved in asthma; the increase of inflammatory factors released after MP infection will also cause exhaled breath.Fractional exhaled nitric oxide(FeNO)is elevated, which can lead to airway hyperresponsiveness and airway remodeling.In view of treatment, when treating MP infections with macrolide drugs, they can also have anti-inflammatory and immunomodulatory effects on the airways, which can reduce the steroid dose required by children with steroid-dependent asthma, reduce the frequency of asthma attacks and prolong remission period in children with asthma.