Progress of MICB/NKG2D signaling pathway in immune escape / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 584-588, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-907283
ABSTRACT
Natural killer group 2 member D(NKG2D) is an immune receptor expressed by NK cells that recognizes the human major histocompatibility complex class I polypetide-related chain(MIC) A/B on the cell surface.The interaction between NKG2D and MICA/B plays an important role in the immunosurveillance of viruses infection and cancers.In this article, we review the research progress of the MICB/NKG2D signaling pathway in immune escape including three parts down-regulation of membrane-bound MICB, increase of secretory MICB, and polymorphism of MICB genes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2021
Type:
Article
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