The mechanism of high mobility group box 1 in coronary artery lesions of Kawasaki disease / 国际儿科学杂志

ABSTRACT

Kawasaki disease(KD)is a common acute febrile vasculitis in children, but the etiology and pathogenesis of KD are unknown.The most serious complication is coronary artery lesions.The damage of vascular endothelial cell may be the key mechanism of coronary artery lesions in KD.It is found that serum levels of high mobility group box 1(HMGB1) increase in the acute phase of KD, especially in children with coronary artery lesions, and that the gene of HMGB1 is associated with coronary artery lesions in Korean children with KD.HMGB1 is a non-histone DNA binding protein related to inflammation, which plays an important role in promoting the apoptosis of coronary artery endothelial cells in KD.The article reviews the mechanism of HMGB1 in coronary artery lesions of KD.