Over-expression of kinesin family member 23 (KIF23) is associated with the development and prognosis of triple-negative breast cancer / 国际生物医学工程杂志

ABSTRACT

Objective:To investigate the expression and clinical significance of kinesin family member 23 (KIF23) in human triple-negative breast cancer (TNBC).Methods:The clinicopathological characteristics of 74 cases of TNBC patients were retrospectively analyzed. The expression of KIF23 in tumor tissues and adjacent normal tissues was detected by immunohistochemical method, and the expression of KIF23 in TNBC patients and its relationship with clinicopathological characteristics were analyzed. The mRNA level of KIF23 in TNBC tissues and normal tissues adjacent to cancer was analyzed by bioinformatics methods, and the relationship between its expression and the survival rate of patients was also analyzed.Results:The results of bioinformatics analysis showed that the high expression of KIF23 in TNBC tissue was significantly related to the overall survival and disease-free survival of patients (all P<0.05). In TNBC tissues, the positive high expression rate of KIF23 was 64.9%, while it was mainly low or no expression in adjacent tissues. The high expression of KIF23 was significantly correlated with the tumor size and pTNM stage of TNBC patients (all P<0.05). Conclusions:KIF23 plays a regulatory role in the progression of TNBC, and it can be used as a new diagnostic and therapeutic target for TNBC.