Research progress of CCL20-CCR6 axis and epithelial-mesenchymal transition in breast cancer / 国际外科学杂志
International Journal of Surgery
;
(12): 401-405, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-907451
ABSTRACT
CCL20 and CCR6 are chemokines produced by a variety of cells. CCL20 and CCR6 combine to stimulate a series of downstream pathways, participate in the occurrence and development of various malignant tumors, and also play an important role in the invasion and metastasis of breast cancer and the process of chemotherapy resistance. Epithelial-mesenchymal transformation (EMT) is a key step in the process of tumor cell metastasis, which is characterized by loss of cell adhesion, down-regulation of E-cherherin expression, up-regulation of mesenchymal markers and fibrinectin expression, and enhancement of cell motor ability and invasion ability. This article reviews the research of CCL20-CCR6 biological axis and EMT on invasion and metastasis of breast cancer cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS