Clinical study on treatment of senile hypertension with Bushen-Yijing-Tiansui Decoction combined with levoclodipine besylate tablets / 国际中医中药杂志
International Journal of Traditional Chinese Medicine
; (6): 847-851, 2021.
Article
in Zh
| WPRIM
| ID: wpr-907642
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ABSTRACT
Objective:To observe the therapeutic effect of Bushen-Yijing-Tiansui Decoction combined with levoclodipine besylate in the treatment of senile hypertension. Methods:A total of 150 elderly hypertensive patients admitted in our hospital from January 2019 to February 2020 were randomly divided into 2 groups by a random number table method, with 75 in each. Both groups were given basic symptomatic treatment of other comorbidities and concurrent health education. The control group received oral amlodipine besylate tablets, and the observation group received Bushen-Yijing-Tiansui Decoction on the basis of the control group. Both groups were treated for 4 weeks. The TCM syndromes were scored before and after treatment, manometer was used to measure blood pressure and heart rate, the serum ET-1 level was detected by Enzyme-Linked Immunosorbent Assay (ELISA), and the nitrate reductase method was used to detect serum NO levels, and adverse events occurred during treatment in the two groups were recorded. Results:The total effective rate of the observation group was 88.0% (66/75), and the control group was 73.3% (55/75), and the comparison difference in 2 groups was statistically significant ( χ2 =5.172, P=0.022). After treatment, the symptom scores of pain, palpitations, constipation, insomina, sore feeling on back and legs of the observation group were signigicantly lower than those in the control group ( t value were 5.814, 10.397, 12.094, 7.019, 6.121, all Ps<0.001). After treatment, heart rate [(79.60 ± 4.80) times/min vs. (84.30 ± 5.40) times/min, t=5.634], SBP [(144.8 ± 7.90) mmHg vs. (150.60 ± 7.90) mmHg, t=4.729], DBP [(78.80 ± 8.20) mmHg vs. (85.20 ± 9.10) mmHg, t=4.525] of the observation group were signigicantly lower than those of the control group ( P<0.01). After treatment, the serum ET-1 [(179.25 ± 30.45) μmol/L vs. (190.83 ± 30.89) μmol/L, t=2.312] of the observation group was signigicantly lower than that of the control group ( P<0.05), NO [(58.51 ± 8.78) μmol/L vs. (54.12 ± 9.03) μmol/L, t=3.019] of the observation group was signigicantly higher than that of the control group ( P<0.05). During treatment, the incidence of adverse events in the control group was 4.0% (3/75), and the observation group was 1.3% (1/75), and the two groups had no significant difference ( χ2 =1.027, P=0.311). Conclusion:Bushen-Yijing-Tiansui Decoction combined with levoclodipine besylate in the treatment of senile hypertension can relieve the clinical symptoms and blood pressure of patients, improve the function of vascular endothelial cells.
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Language:
Zh
Journal:
International Journal of Traditional Chinese Medicine
Year:
2021
Type:
Article