Decorin and TGF-beta Expression after Partial Myotomy of the Extraocular Muscle in Rat
Journal of the Korean Ophthalmological Society
;
: 143-148, 2013.
Article
in Korean
| WPRIM
| ID: wpr-90779
ABSTRACT
PURPOSE:
To report the expression of decorin and TGF-beta in partial myotomy of the extraocular muscle in rats.METHODS:
Partial myotomy of the superior rectus muscle was performed on the right eye of 10 Sprague-Dawley rats followed by exposure of the left superior rectus muscle and a simple suture of the conjunctiva. The bilateral superior rectus muscle was obtained from all rats at 2 weeks postoperatively. The tissues were observed under light microscopy with hematoxylin-eosin, Masson's trichrome staining and immunohistochemistry.RESULTS:
Histological examinations of the surgical area at 2 weeks after postoperatively showed irregularly concentrated fibrosis on light microscopy with hematoxylin-eosin and Masson's trichrome staining of the experimental eyes. Immnohistochemistry showed that expression of decorin was in the same location as TGF-beta in the experimental group.CONCLUSIONS:
The expression of decorin was found in the healing process after partial myotomy of the extraocular muscle in rats. Immunohistochemistry showed that expression of decorin was in the same location as with TGF-beta.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sutures
/
Fibrosis
/
Immunohistochemistry
/
Transforming Growth Factor beta
/
Rats, Sprague-Dawley
/
Conjunctiva
/
Decorin
/
Microscopy
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2013
Type:
Article
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