Biotherapy trends in asthma: from the discovery of IgE to anti-IgE antibody production / 中华实用儿科临床杂志

ABSTRACT

Asthma is the most common chronic respiratory disease in children.Currently, asthma symptoms can be well controlled under initial treatment.For moderate and severe asthma that cannot be controlled by initial treatment, biological therapy is a new option.Among them, the anti-IgE antibody (Omalizumab) is the earliest biological agent to be marketed for the treatment of asthma, followed by a large number of novel monoclonal antibodies targeting different sites.In this paper, the immune mechanism, classification and the development history of biological therapy of asthma were summarized, and the trends of biological therapy of asthma were prospected.