Clinical characteristics and progress in diagnosis and treatment of drug reactions with eosinophilia and syste-mic symptoms in children / 中华实用儿科临床杂志

ABSTRACT

Drug reactions with eosinophilia and systemic symptom (DRESS) are a severe drug eruption, which is characterized by fever, rash, lymphadenopathy, hematological system abnormalities and involvement of internal organs.It also has such clinical characteristics as delayed onset, relapsing symptoms and reactivation of human herpesvi-ruses.The clinical characteristics of DRESS make it different from other drug reactions, with high clinical heterogeneity, variability and unpredictability.DRESS in children has some unique characteristics that are different from adults, such as culprit drugs, rash characteristics, and involved systems and organs.Moreover, the course of disease is shorter, the severity is milder, the morbidity and mortality are lower, and the prognosis is better compared with adults.In this paper, the clinical characteristics and progress in diagnosis and treatment of DRESS in children are reviewed.