Effect of DHEA Administration before, during and after Dexamethasone Treatment on Body Weight and Mass of TypeI, II Muscles in Rats / 간호학회지
Journal of Korean Academy of Nursing
;
: 727-734, 2002.
Article
in Korean
| WPRIM
| ID: wpr-90815
ABSTRACT
PURPOSE:
This study was to determine the effect of DHEA administration before, during, and after dexamethasone treatment on body weight and TypeI,II muscle weight of rat receiving dexamethasone treatment.METHOD:
Wistar rats were divided into 6 groups control(C), dexamethasone(D), DHEA administration for 3days after dexamethasone treatment for 7days(7D+3DH), dexamethasone treatment for 7days after DHEA administration for 3days(3DH+7D), DHEA administration during dexamethasone treatment for 4days after dexamethasone treatment for 3days(3D+4DDH), DHEA administration during dexamethasone treatment for 7days(7DDH). Dexamethasone was injected by subcutaneously daily at a dose of 5mg/kg. DHEA was orally administered daily at a dose of 5mg/kg for 7 days. Soleus(TypeI) muscle, and both plantaris and gastro- cnemius(TypeII) muscles were dissected on the 7th day of experiment.RESULT:
Body weight of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Body weight of 7D+3DH group decreased significantly compared with that of 7D group, 7DDH group, 3DH+7D group and 3D+4DDH group. Muscle weight of both plantaris and gastro- cnemius tended to decrease compared with that of 7D group. Muscle weight of 7DDH group, 3D+4DDH group and 3DH+7D group increased significantly compared with that of 7D+3DH group. Muscle weight of gastrocnemius of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group.CONCLUSION:
Based on these results, it can be suggested that DHEA administration before and during dexamethasone treatment can increase both body weight and mass of atrophied TypeII muscle induced by dexa- methasone treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Weight
/
Dexamethasone
/
Rats, Wistar
/
Dehydroepiandrosterone
/
Muscles
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Academy of Nursing
Year:
2002
Type:
Article
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