Prevention of Hypokalemia before Induction of Anesthesia by Clonidine or Midazolam / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 920-924, 1998.
Article
in Korean
| WPRIM
| ID: wpr-90822
ABSTRACT
BACKGROUND:
Selective 2-agonists cause decrease in serum K+ concentration. Midazolam is an anxiolytic, sedative, and amnestic drug. Premedication of midazolam prevents increase of catecholamine with anxiety. Clonidine, alpha 2-adrenergic receptor agonist, supresses sympathetic outflow from central nervous system. So we can expect that premedication of clonidine or midazolam will prevent hypokalemia before induction of anesthesia.METHODS:
Twenty two patients received 300 mcg clonidine per oral, 22 patients 0.05 mg/kg midazolan IM and 22 patients had no premedication. We measured serum K+ level at out-patient Department (T1), at 1100 P.M. of the day before surgery (T2) and immediately before induction of anesthesia (T3).RESULTS:
Serum K+ levels at T2 decreased compared to serum K+ level at T1 in all groups. Serum K+ levels T3 decreased compared to serum K+ level at T2 in control and midazolam groups but clonidine group did not decrease in serum K+ level.CONCLUSIONS:
We can not prevent decrease of serum K+ level with premedication of midazolam but we can prevent decrease of serum K+ level with premedication of clonidine. So premedication of clonidine is more effective than midazolam in prevention of hypokalemia before induction of anesthesia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Outpatients
/
Premedication
/
Midazolam
/
Central Nervous System
/
Clonidine
/
Hypokalemia
/
Anesthesia
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1998
Type:
Article
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