Investigation of Toxoplasma gondii infection in patients with three common gynecological malignant tumors / 中国实用护理杂志

ABSTRACT

Objective:To explore the infection of Toxoplasma gondii in patients with common gynecological malignancies and to explore the correlation between gynecological malignancies and Toxoplasma gondii infection, so as to provide basis for the prevention and control of Toxoplasma gondii infection in such population in the future. Methods:Patients with gynecological malignancies (114 cases of ovarian cancer, 107 cases of cervical cancer and 110 cases of endometrial cancer) treated in Shengjing Hospital of China Medical University from January 2018 to January 2020 were selected as the study group, and 200 women with normal physical examination during the same period were selected as the control group.Enzyme linked immunosorbent assay was used to detect serum anti Toxoplasma gondii IgM and IgG antibodies in the two groups. Results:The overall Toxoplasma gondii infection rate and the overall serum anti- Toxoplasma gondii IgG antibody positive rate in the study group were 26.89%(89/331) and 26.28%(87/331), respectively, which were higher than 5.00%(10/200) of the control group, and the results were significantly different( χ2 values were 39.32, 37.73, P<0.01). The positive rates of anti- Toxoplasma gondii IgG antibody in patients with ovarian cancer, cervical cancer and endometrial cancer of the study group were 28.07%(32/114), 25.23%(27/107) and 25.45%(28/110), respectively, which were higher than those in the control group (5.00%,10/200)( χ2 values were 32.26, 27.32, 28.00, all P<0.01). Conclusions:The positive rate of Toxoplasma gondii infection in gynecological malignant tumor patients with low immune function is high, which should be paid enough attention by medical staff to strengthen the prevention and control of infection.