Management of edema in children with nephrotic syndrome / 中国小儿急救医学

ABSTRACT

Edema is one of the main clinical manifestations of nephrotic syndrome (NS), and also the chief complaint to visit a doctor.The condition significantly affects the quality of life in children with NS, and can cause a variety of comorbidities in severe cases, which can be life-threatening without handling properly.For children with steroid-sensitive NS, the edema can be completely resolved after the glucocorticoid therapy.Whereas for many children with steroid-resistant NS or hereditary NS, symptomatic treatment for edema is essential.A variety of mechanisms are involved in the occurrence of edema in children with NS, and more targeted treatments based on the mechanisms may achieve better curative effects and avoid drug side effects.