Progress of some apoptosis-related microRNAs in bronchopulmonary dysplasia / 中国小儿急救医学

ABSTRACT

Bronchopulmonary dysplasia(BPD)is a common chronic lung disease during the newborn period.It not only affects the quality of life of the children, but causes complications that have a certain impact on the future growth and development of them.Currently, there is still a lack of specific prevention and treatment measures.MicroRNAs(miRNAs)are a class of endogenous small molecule non-coding RNAs.In recent years, some abnormally-expressed miRNAs have been found to be involved in the pathogenesis of BPD through regulating apoptosis pathway, but the specific pathogenic link and mechanisms are still not clear enough.In this article, the molecular mechanisms of miRNAs involved in apoptosis in the pathogenesis of BPD were reviewed to provide a theoretical basis for exploring new diagnosis and treatment methods for BPD.