Progress on role of intestinal flora in the treatment of epilepsy / 中国小儿急救医学

ABSTRACT

Epilepsy is one of the common diseases of nervous system.Most children′s epilepsy can be controlled by drug treatment, but 20%—30% of children with epilepsy still have poor control effect after treatment, and eventually develop into intractable epilepsy, which seriously affects their healthy growth.In recent years, it has been found that the intestinal flora has two-way connection with the brain through the brain-intestine axis, including vagus nerve, neuroendocrine hypothalamic-pituitary-adrenal axis, intestinal immune system, neurotransmitters and neuroregulatory factors, which have a significant impact on the physiological, behavioral and cognitive functions of the brain, thus playing a role in the occurrence and development of epilepsy.Intestinal flora is closely related to epilepsy and may be a target for epilepsy treatment.Therefore, this review summarized the potential role of intestinal flora in epilepsy treatment.