Pathological features of 6 cases with primary pancreatic schwannoma / 中华胰腺病杂志

ABSTRACT

Objective:To investigate the clinicopathological features of primary pancreatic schwannoma.Methods:The clinicopathological features of 6 cases with pancreatic schwannoma admitted in the First Affiliated Hospital of Naval Medical University from October 2010 to September 2017 were retrospectively analyzed. The expressions of mesenchymal marker vimentin and neurogenic markers including S100, ABC, β-tub, NGFR, SOX-10 and CD 34, CD 117 were detected by immunohistochemistry. Results:In the 6 cases of pancreatic schwannoma, there were 2 men and 4 women. The male to female ratio was 1∶2. The patient age ranged from 36 to 76 years old, and the median age was 48 years old. One tumor was located in the head, two in the neck, two in the body and one in the tail of pancreas. Preoperative imaging findings showed that the 6 cases of pancreatic schwannoma were all single lesion, 3 were solid, and the other 3 were cystic solid. Among the 6 cases, 5 cases underwent radical operation and 1 case underwent tumor resection. Macroscopically, the mass was clearly separated from the surrounding tissue, and the section surface was yellowish, translucent with hemorrhage and cystic changes. Microscopicalliy, typical features of pancreatic schwannoma included A region (zona fasiculata) and B region (zona reticularis). The immunohistochemical results found the positive staining of vimentin, S100, ABC, β-Tub and SOX-10, negative staining of CD 34 and CD 117. NGFR was positively expressed in 4 cases but negatively expressed in 2 cases. All patients had a good prognosis. No recurrence or metastasis was observed. Conclusions:The pathological features of pancreatic schwannoma was obvious and the clinical prognosis was good.