Genetic regulation of microvascular proliferation under high altitude hypoxia / 中华地方病学杂志

ABSTRACT

Hypoxia is a typical characteristic of the high altitude environment. Chronic hypoxia arises due to the excessive production of erythrocytes, which increases the blood viscosity causing blood flow retardation to exacerbate hypoxic-ischemic injury and eventually angiogenesis. The "blood rich face" of people who have lived in high altitude for a long time is a typical representative of microvascular proliferation. In recent years, the mechanism of microvascular proliferation under high altitude hypoxia has become a hot topic at home and abroad. Therefore, the pathways and genes of microvascular proliferation under high altitude hypoxia are reviewed in this paper.