Repeated transcranial magnetic stimulation in the treatment of mixed depression and anxiety in 35 patients / 中国基层医药

ABSTRACT

Objective:To investigate the efficacy of repeated transcranial magnetic stimulation in the treatment of mixed depression and anxiety.Methods:Sixty-nine patients with mixed depression and anxiety who received treatment in The Second People's Hospital of Lishui from June 2018 to June 2019 were included in this study. They were randomly assigned to receive either conventional anti-anxiety and anti-depression medications (control group, n = 34) or repeated transcranial magnetic stimulation based on conventional anti-anxiety and anti-depression medications (observation group, n = 35) for 4 weeks. Therapeutic efficacy, quality of life, anxiety and depression scores, and adverse reactions were compared between the two groups. Results:Total effective rate in the observation group was significantly higher than that in the control group [97.14% (34/35) vs. 79.41% (27/34) , χ2 = 5.289, P < 0.05]. Before treatment, there were no significant differences in the scores of mental health, physical functioning, general health and role emotional between the two groups (all P > 0.05). After treatment, the scores of mental health, physical functioning, general health and role emotional in each group were significantly increased compared with before treatment (all P < 0.05). In addition, after treatment, the scores of mental health, physical functioning, general health and role emotional in the observation group were significantly higher than those in the control group ( t = 5.982, 5.130, 5.232, 4.829, all P < 0.05). Before treatment, there were no significant differences in anxiety and depression scores between the two groups (both P > 0.05). After treatment, the anxiety and depression scores in each group were significantly decreased compared with before treatment (both P < 0.05). After treatment, the anxiety and depression scores in the observation group were significantly lower than those in the control group ( t = 8.465, 9.290, both P < 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group [8.57% (3/35) vs. 17.64%(6/34), χ2 = 4.138, P < 0.05). Conclusion:Repeated transcranial magnetic stimulation is highly effective in the treatment of mixed depression and anxiety. It can effectively reduce the depression and anxiety symptoms, improve the quality of life, is highly safe, and therefore deserves clinical popularization.