Research progress on pathogenesis of cancer cachexia / 中华临床营养杂志
Chinese Journal of Clinical Nutrition
;
(6): 59-64, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-909323
ABSTRACT
Cancer cachexia is a complex metabolic syndrome characterized by muscle wasting, fat decomposition, unplanned weight loss, anorexia and immune dysfunction. Cachexia can significantly reduce the efficacy of antitumor therapies and increase treatment-related toxicity on cancer patients. It increases the symptom burden in patients, affects the quality of their life, ultimately shortens patients' survival. Lucubrating the pathogenesis of cachexia is of great significance to provide rationale treatment guidance. Here we reviewed the research progress on pathogenesis of cancer cachexia, including inflammatory response mediated by TNF-α, IL-1, IL-6 and STAT-3 and abnormal nutrition metabolism, as well as mitochondrial dysfunction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Practice guideline
Language:
Chinese
Journal:
Chinese Journal of Clinical Nutrition
Year:
2021
Type:
Article
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