Effects of probiotics supplementation on the prevention and treatment of gestational diabetes mellitus: a systematic review / 中华临床营养杂志

ABSTRACT

Objective:To systematically review the effects of probiotics supplementation on the prevention and treatment of gestational diabetes mellitus (GDM).Methods:Computerized literature search (CNKI, Wanfang, CBM, VIP, PubMed, Web of science, Embase, and Cochrane Library) as well as manual search was conducted to collect relevant studies. Data were extracted from qualified literature per pre-defined selection criteria and the risk of bias was evaluated. Systematic review was conducted using Stata 11.0 and Revman 5.3 software.Results:Six studies were included in the systematic review of the prevention effects of probiotics on GDM. The results showed that probiotics supplementation was not associated with the incidence of GDM ( RR=0.84, 95% CI 0.53~1.34). Moreover, probiotics supplementation may be not associated with the level of glucose, either. Twelve studies were included in the systematic review of the treatment effects of probiotics on GDM. The results showed that in GDM patients, probiotics supplementation could decrease the levels of fasting blood glucose ( WMD=-2.06, 95% CI -3.95~-0.17), fasting serum insulin ( SMD=-0.61, 95% CI -0.79~-0.42), insulin resistance index as assessed by homeostatic model assessment ( WMD=-0.64, 95% CI -0.86~-0.43), triglycerides ( WMD=-21.96, 95% CI -36.15~-7.78), total cholesterol ( WMD=-10.63, 95% CI -19.43~-1.83), high-sensitivity C-reactive protein ( SMD=-0.77, 95% CI -1.00, -0.53), and cesarean section rate ( RR=0.57, 95% CI 0.38~0.83). Conclusions:Probiotics supplementation could not prevent the onset of GDM but seems beneficial in the treatment of GDM. More studies are needed in the future to explore the effects of probiotics supplementation on GDM.