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Research progress on regulated necrosis in acute kidney injury / 中华危重病急救医学
Chinese Critical Care Medicine ; (12): 885-888, 2021.
Article in Chinese | WPRIM | ID: wpr-909424
ABSTRACT
Regulated necrosis is a newly discovered new cell death pathway, including necroptosis, pyroptosis and ferroptosis. It has been reported to play a key role in acute kidney injury (AKI) induced by ischemia/reperfusion, cisplatin and other drugs, and rhabdomyolysis. Studying the role of regulated necrosis-related pathways in AKI is expected to provide a new direction for clarifying the pathogenesis and treatment of AKI, with potential therapy and application prospects. In this review, we summarize the related signaling pathways of necroptosis, pyroptosis and ferroptosis, and the related research progress in AKI, in order to provide potential targets for the prevention and treatment of AKI.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Critical Care Medicine Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Critical Care Medicine Year: 2021 Type: Article