Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria
Allergy, Asthma & Immunology Research
; : 522-526, 2016.
Article
in En
| WPRIM
| ID: wpr-90956
Responsible library:
WPRO
ABSTRACT
PURPOSE: Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis of the disease in children. This study investigated the possible role of metalloproteinase-9 (MMP-9) in the pathogenesis of CSU in children. METHODS: The study group was composed of 54 children with CSU; 34 healthy children comprised the control group. The demographic and clinical features of the study group were extensively evaluated, and laboratory assessments were also performed. An enzyme-linked immunosorbent assay was used to evaluate levels of plasma MMP-9. Disease activity was quantified using the urticaria activity score (UAS). RESULTS: The median value of plasma MMP-9 was 108.9 ng/mL (interquartile range, 93.3-124.1) in the CSU group and 87.8 ng/mL (69.4-103.0) in the control group. The difference between the 2 groups was statistically significant (P0.05). CONCLUSIONS: Plasma MMP-9 levels were elevated in children with CSU and were positively correlated with disease activity. MMP-9 may be both a good biomarker of disease activity and a potential therapeutic target in CSU.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Urticaria
/
Enzyme-Linked Immunosorbent Assay
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Skin Tests
/
Matrix Metalloproteinase 9
Limits:
Adult
/
Child
/
Humans
Language:
En
Journal:
Allergy, Asthma & Immunology Research
Year:
2016
Type:
Article