Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea
Allergy, Asthma & Immunology Research
;
: 505-511, 2016.
Article
in English
| WPRIM
| ID: wpr-90958
ABSTRACT
PURPOSE:
Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy.METHODS:
Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis).RESULTS:
After peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries.CONCLUSIONS:
Ara h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arachis
/
Pollen
/
Trees
/
Immunoglobulin E
/
Allergens
/
Rhinitis, Allergic, Seasonal
/
Betula
/
Peanut Hypersensitivity
/
Food Hypersensitivity
/
Hypersensitivity
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2016
Type:
Article
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