Correlation between serum calcium level and disease severity of acute obstructive suppurative cholangitis / 中国医师杂志

ABSTRACT

Objective:To investigate the correlation between serum calcium level and patients with acute obstructive suppurative cholangitis (AOSC).Methods:The clinical data of 104 patients with AOSC treated in the emergency room of Beijing Friendship Hospital Affiliated to Capital Medical University from June 2019 to February 2020 were retrospectively selected, of which 53 patients with severe sepsis were included in group A, 51 patients with simple AOSC were included in group B, and 50 patients with non infectious severe diseases hospitalized in the same period were selected as control and included in group C. The levels of serum calcium, C-reactive protein (CRP), procalcitonin (PCT) and D-dimer (D-D) were compared in the three groups. Pearson analysis was used to analyze the correlation between serum calcium and CRP, PCT and D-D.Results:The levels of serum calcium in group A were significantly lower than those in group B and group C, and the levels of inflammatory related factors CRP, PCT and D-D were significantly higher than those in group B and group C ( P<0.01), with significant difference. In AOSC group, serum calcium was negatively correlated with CRP, PCT and D-D levels ( r=-0.550, -0.479, -0.431, P<0.05). Conclusions:Patients with AOSC are prone to hypocalcemia under infection, and the level of serum calcium is negatively correlated with infection inflammatory indexes CRP, PCT and D-D, indicating that the level of calcium is related to the severity of infection. Hypocalcemia should be found in time in clinical work, and the severity of the disease should be evaluated as soon as possible.