Research progress in effect of immune system and immunomodulatory drugs on fracture healing / 中华创伤杂志

ABSTRACT

Fracture healing is a complex biological process. After a fracture, a hematoma will first form at the injured site, and immune cells and inflammatory factors will quickly reach the fracture site to facilitate the repair and reconstruction of bone tissue. Immune cells and inflammatory factors are an important part of the body's immune system, and the immune system plays a key role in removing necrotic tissue and maintaining the homeostasis of the body's environment. Proper immune regulation after a fracture is beneficial to fracture healing; if immune regulation is improper, the fracture site will gradually develop into a chronic inflammatory state, which may impair healing. The authors summarize the mechanism of action of the innate immune system and adaptive immune system in fracture healing, as well as the research progress of therapeutic drugs that affect the state of the immune system and thus affect the healing of fractures, so as to deepen the understanding of the immune system affecting bone regeneration and provide new ideas for clinical treatment of fracture.