Pay attention to role of bone marrow adipose tissue in the regulation of osteoporotic fracture healing / 中华创伤杂志

ABSTRACT

The osteoporotic fracture is characterized by a high disability rate，poor internal fixation strength，delayed bone healing，etc.，which greatly affects elderly health，so accelerating fracture healing is the key point of therapeutic strategies. Current researches mainly concentrate in bone formation acceleration and resorption inhibition，but the outcomes turn out to be unsatisfactory under the coupling of osteoblasts and osteoclasts. The accumulation of yellow adipose tissue in the medullary cavity is often arisen in patients with osteoporotic fractures，but its role and mechanism in bone metabolism remain unclear. Bone marrow adipocytes are differentiated from mesenchymal stromal cells and possess unique metabolic and secretory functions involving in energy metabolism，maintenance of hematopoietic microenvironment and regulation of bone metabolism balance. However，the role of bone marrow adipose tissue（BMAT）in osteoporotic fracture healing requires more elucidation. In this study，the authors discuss the key role and molecular mechanism of BMAT in the regulation of bone metabolism and homeostasis，aiming to provid new ideas and targets for the promotion of osteoporotic fracture healing.