Research progress in mechanism of H-type vessel on the coupling of angiogenesis and osteogenesis in bone microenvironment remodeling / 中华创伤杂志
Chinese Journal of Trauma
;
(12): 1048-1054, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-909975
ABSTRACT
The coupling effect of angiogenesis and osteogenesis is of great significance for the remodeling of bone microenvironment. As a bone-specific microvascular subtype with high expression of CD31 and Endomucin(CD31 hiEmcn hi),H-type vessels are mainly distributed in the metaphysis,surrounded by Osterix + and Runt-related transcription factor 2(Runx2 +)osteogenic progenitor cells. H-type vessels,regulated by vascular endothelial growth factor(VEGF),platelet-derived growth factor BB(PDGF-BB),slit guidance ligand 3(SLIT3),hypoxia inducible factor 1α(HIF-1α),Notch and other signals,participate in the regulation of cell proliferation and differentiation of bone marrow mesenchymal stem cells(BMSCs),osteoblasts,osteoclasts,endothelial cells,etc. The mechanism of H-type vessels in coupling osteogenesis with angiogenesis has become a hot spot in recent research. The authors explore the progress of the mechanism of H-type vessels in coupling osteogenesis with angiogenesis by reviewing the characteristics of H-type vessel,mechanism of H-type vessel regulating bone formation,regulation mechanism of H-type vessel formation and related influencing factors,to provide a reference for clinical bone injury repair and anti-osteoporosis treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Practice guideline
Language:
Chinese
Journal:
Chinese Journal of Trauma
Year:
2021
Type:
Article
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