Treatment strategies for acute severe cholangitis / 中华肝胆外科杂志

ABSTRACT

Acute severe cholangitis is a serious disease with fast development and high mortality. The therapeutic options are stills limited. Once diagnosed, the key step of treatment is to timely reduce the high pressure of bile duct caused by biliary obstruction, and to block bacteria and toxins from entering the blood, which might trigger inflammation " cascade reaction" . The policy of " relieve obstruction, remove lesions, and bile duct drainage" raised by academician Huang Zhiqiang, is still the criterion for acute cholangitis treatment. Active biliary drainage, early continuous renal replacement therapy, and simultaneous antibacterial therapy and multi-organ function support can significantly improve the disease outcome and reduce mortality.