The effect of weight loss on endothelial function and cerebrovascular risk factors in obese and overweight people / 中华健康管理学杂志

ABSTRACT

Objective:To explore the effect of weight loss on endothelial function and cerebrovascular risk factors in obese and overweight people.Methods:A total of 127 obese or overweight subjects received 6-month body weight management. Subjects who lost 3 kg or more than 5% of their body weight prior to the 6-month intervention were defined as achievement group. Endothelial function (FMD) and other cerebrovascular risk factors were measured before and after intensified lifestyle management.Results:The achievement group comprised 57 (44.9%) cases and the non-achievement group 70 (55.1%) cases. After 6-month intervention, FMD (6.98±2.88% vs 7.90±2.96%, P<0.05) and HDL-C increased in the achievement group. Significant decreases were observed in the achievement group in BMI, SBP, DBP, FPG, TC, LDL-C, TG and uric acid. However, only DBP and FPG decreased in the non-achievement group. Conclusion:Weight loss can reverse endothelial dysfunction and metabolic dysfunction. Decrease of body fat ratio contributes to the improvement of endothelial function.