Correlation analysis of blood pressure with serum creatinine and glomerular filtration rate / 中华健康管理学杂志

ABSTRACT

Objective:To investigate and analyze the correlation between blood pressure and serum creatinine (Scr) and glomerular filtration rate (GFR).Methods:This research was a cross-sectional study, a total of 46792 people over 20 years old with relatively complete data in the health management center of the First Affiliated Hospital of Xinjiang Medical University from January to December 2018 were included as the research subjects, and baseline data of these study subjects were obtained by on-site questionnaire, collection of blood pressure, creatinine and other physiological and biochemical indicators. The subjects were divided into 20-64 years old group and ≥65 years group according to their age; being treated as the continuous variables (systolic blood pressure, diastolic blood pressure, five categories), their blood pressure indicators were analyzed. The F test, t test, χ2 test and logistic regression model were used to analyze the baseline characteristics of Scr level and GFR, as well as the correlation between blood pressure and Scr and GFR. Results:(1) The average Scr level was (72.89±16.84) μmol/L in the study population aged 20-93. The average GFR was (102.17±17.01) ml·min -1·(1.73 m 2) -1. The average Scr of men was higher than that of women, the average GFR of men was lower than that of women (all P<0.001). (2) Among the subjects above, there were 514 cases (1.10%) with abnormal Scr level and 657 cases (1.40%) with abnormal GFR, the incidence of abnormal Scr and GFR was higher in men, subjects with age ≥65 years old, or diabetes, or hypertension (all P<0.05). (3) There were significant differences in Scr level and GFR in subjects with different gender, age, blood pressure and body mass index (BMI) (all P<0.05). (4) With the increase of blood pressure, among the crowd of 24-64 years old, the relative risk of abnormal Scr and GFR in the group with baseline blood pressure ≥180/110 mmHg was 8.434 and 5.168 times higher than that in the group with baseline blood pressure<120/80 mmHg, respectively, after adjusting variables such as sex, age, nationality, BMI, hypertension, diabetes. However, among the crowd of ≥65 years old, only the relative risk in the group with baseline blood pressure of 160-179/100-109 mmHg was statistically significant compared with<120/80 mmHg. Conclusion:The blood pressure is bound up with Scr and GFR in the crowd of 24-64 years old.