Analysis of long-term survival of elderly patients with differentiated thyroid cancer after surgery and its influencing factors / 中华老年医学杂志

ABSTRACT

Objective:To examine the long-term survival of elderly patients with differentiated thyroid cancer(DTC)after surgery, and to analyze its influencing factors.Methods:Clinical data of 80 elderly DTC patients from our department who had completed a 5-year post-surgery follow-up between January 2017 and June 2020 were analyzed.The survival characteristics and survival time of patients were analyzed.The difference in mortality was compared in patients with different general conditions.Influencing factors for long-term survival in elderly DTC patients 5 years after surgery were analyzed by using Cox regression.Results:Of 80 elderly DTC patients, the average survival time was 4.53±0.41 years, 18 cases died during the follow-up period, the mortality was 22.50%(18/80), and the survival rate was 77.50%(62/80). Cox regression analysis showed that histological type(follicular thyroid cancer), surgical method(unilateral gland resection), no cervical lymph node dissection and low therapeutic doses of iodine were influencing factors for the long-term survival of elderly DTC patients 5 years after surgery( OR=5.888, 5.795, 6.753 and 4.923, P=0.004, 0.004, 0.002 and 0.003). Conclusions:The 5-year long-term survival of elderly DTC patients may be affected by the histological type, surgical method, cervical lymph node dissection and therapeutic doses of iodine.Clinical management with an emphasis on these factors and with targeted risk mitigation intervention plans may offer a positive impact on the long-term survival for patients.