Significant changes of bronchial responsiveness to methacholine after early asthmatic reaction to toluene diisocyanate (TDI) in a TDI-sensitive asthmatic worker
Journal of Korean Medical Science
;
: 185-188, 1990.
Article
in English
| WPRIM
| ID: wpr-91163
ABSTRACT
Current asthma is often diagnostically excluded by the presence of normal bronchial responsiveness. We report on a TDI-induced occupational asthma patient with normal bronchial responsiveness. He had suffered from shortness of breath during and after TDI exposure for several months. His initial methacholine bronchial challenge test showed a negative response. The bronchoprovacation test with TDI showed an isolated immediate bronchoconstriction. The following methacholine bronchial challenge tests revealed that the bronchial hyperresponsiveness developed seven hours after the TDI challenge (methacholine PC205.1 mg/ml), progressed up until 24 hours, and returned to normal on the seventh day. This case provides evidence that the response of the airway to TDI may not always be accompanied by bronchial hyperresponsiveness to methacholine. Screening programs utilizing methacholine challenges may not always identify TDI-sensitized asthmatic workers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Time Factors
/
Bronchial Provocation Tests
/
Skin Tests
/
Bronchoconstriction
/
Methacholine Chloride
/
Toluene 2,4-Diisocyanate
/
Occupational Diseases
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1990
Type:
Article
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