Animal models of Guillain-Barré syndrome / 中华神经科杂志

ABSTRACT

Guillain-Barré syndrome (GBS) is an autoimmune-mediated peripheral neuropathy. The main therapeutic strategies for GBS are intravenous immunoglobulin and plasma exchange; however, a part of patients respond not well to current strategies. The definite mechanism of GBS remains not clear and animal models are powerful tools to investigate the pathogenesis of GBS and explore new treatments. Till now, a series of animal models have been established. This paper is aimed to review these models with focus on their characteristics, advantages and disadvantages, which will be helpful for the further experimental studies of GBS.