Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs
Korean Journal of Veterinary Research
;
: 47-50, 2017.
Article
in English
| WPRIM
| ID: wpr-91207
ABSTRACT
Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Hydrocortisone
/
Radioimmunoassay
/
Cerebrospinal Fluid
/
Dehydroepiandrosterone
/
Diagnosis
/
Epilepsy
Type of study:
Diagnostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Veterinary Research
Year:
2017
Type:
Article
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