Meta-analysis of subfoveal choroidal thickness changes in amblyopia based on spectral-domain optical coherence tomography / 中华眼底病杂志

ABSTRACT

Objective:To evaluate the changes in subfoveal choroidal thickness (SFCT) in amblyopic eyes.Methods:A evidence-based medicine study. Chinese and English as search terms for amblyopia and choroid was used to search literature in Wanfang, CNKI, and PubMed of National Library of Medicine. Incomplete or irrelevant literature and review literature were excluded. The literature was meta-analyzed using STATA 15.0. The weighted mean difference (WMD) and 95% confidence interval ( CI) were selected as the estimated value of effect size, and subgroup analysis and sensitivity analysis were used to detect the source of heterogeneity. Results:According to the search strategy, 75 articles were initially retrieved, and 15 articles were finally included for meta-analysis. A total of 650 patients with amblyopia, aged 3 to 65 years old, were included. The enhanced depth imaging technology of spectral domain optical coherence tomography was used to measure SFCT. The results of meta analysis showed that SFCT of amblyopic eyes was more effective than the contralateral eye (WMD=18.89 μm, 95% CI 14.81-22.98 μm, P<0.001) and normal eyes were thicken (WMD=39.49 μm, 95% CI 33.88-45.09 μm, P<0.001). There was no statistically significant difference in SFCT between anisometropic and strabismic amblyopia eyes (WMD=-5.03 μm, 95% CI -19.50-9.44 μm, P=0.495). Conclusions:The SFCT of amblyopic eyes in amblyopic patients is thicker than that of the contralateral eye and normal eyes. There is no difference in SFCT between anisometropia and strabismus amblyopia.