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Relationship between VEGF gene polymorphism and diabetic retinopathy in Li nationality type 2 diabetic patients in Hainan / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science ; (12): 322-326, 2022.
Article in Chinese | WPRIM | ID: wpr-913046
ABSTRACT
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AIM:

To assess the association of vascular endothelial growth factor(VEGF)gene polymorphisms(rs2010963 and rs3025039)with diabetic retinopathy(DR)in Li nationality type 2 diabetic(T2DM)patients in Hainan.

METHODS:

Prospective study. A total of 89 patients with T2DM in the Li nationality in Hainan were randomly categorized(between 09/2016 to 10/2019)into three groups, 30 patients in nonproliferative diabetic retinopathy(NPDR)group, 33 patients in proliferative diabetic retinopathy(PDR)group, and 26 patients in T2DM without retinopathy(DWR)group as control. Polymerase chain reaction-restriction fragment length polymorphism method was used to determine the polymorphism in the VEGF gene. Differences in allele frequencies and genotype frequencies between cases and controls were compared.

RESULTS:

Compared with the DWR group, the CC genotype of rs2010963 polymorphic site was significantly increased(<i>P</i><0.016667), and CG genotype was significantly decreased in PDR group(<i>P</i><0.016667). No significant differences were detected in the frequencies of genotype GG and C, G allele distribution among the three groups(<i>P</i>>0.05). Meanwhile, no significant differences were detected in the frequencies of genotype CC, CT, C, and T in rs3025039 among the three groups(all <i>P</i>>0.05). Plasma levels of serum urea and creatinine were significantly increased in PDR group compared to DWR and NPDR groups in Li nationality group in Hainan(all <i>P</i><0.05).

CONCLUSION:

The polymorphism of the VEGF gene(rs2010963)is associated with DR. CC genotype may be a genetic risk factor for the development of DR, increasing susceptibility to PDR. The rs2010963 related genotype is conferred risk and associated with higher susceptibilities of PDR.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Risk factors Language: Chinese Journal: International Eye Science Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Risk factors Language: Chinese Journal: International Eye Science Year: 2022 Type: Article