Recent advances in thrombolysis of acute ischemic stroke
Journal of the Korean Medical Association
;
: 402-409, 2013.
Article
in Korean
| WPRIM
| ID: wpr-91326
ABSTRACT
Among the many advances in acute ischemic stroke (AIS) management, thrombolysis with intravenous (IV) tissue plasminogen activator (tPA) within 3 hours after symptom onset has been the only approved pharmacological therapy in AIS. However, IV administration of tPA has many limitations in clinical practice, and the proportion of eligible patients remains quite low. Many clinical trials have attempted to overcome this by increasing the therapeutic time window and enhancing the efficacy of reperfusion by the intra-arterial (IA) approach with novel mechanical devices. In addition, the application of new thrombolytic agents and identification of suitable thrombolytic candidates by multimodal brain imaging is another field of active research in thrombolytic therapy. We reviewed AIS management, focusing on thrombolysis with IV therapy, IA therapy, and IV-IA bridging therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reperfusion
/
Thrombolytic Therapy
/
Tissue Plasminogen Activator
/
Stroke
/
Neuroimaging
/
Fibrinolytic Agents
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Medical Association
Year:
2013
Type:
Article
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