8MHz RF Capacitive Heating on Rabbit Lung / 대한치료방사선과학회지

ABSTRACT

The usefulness of hyperthermia for cancer therapy has been established. The purpose of the present investigation was to access feasibility of heating normal lung and the temperature and power requirement were compared with that for liver as solid organ in rabbits by using radiofrequent heating machine. In this study, 20 rabbits were divided into 2 groups according to the heating site and the method of temperature measurement ; in group I lung heating and temperature measuring in skin, esophagus and lung parenchyme ; in group ll liver heating and temperature measuring in skin and liver parenchyme. The results were as follows ; 1) When the maximum temperature was almost same in lung heating group and liver heating group, the power for liver heating was lesser required than the power for lung heating (p<0.05). 2) The temperature of esophagus for the measurement of mediastinum temperature was 1.1+/-0.9 degrees C higher than the temperature of lung parenchyme (p<0.05). Therefore the above findings suggest lung, air containing organ, is well heated as same as liver, solid organ. So more active trials of lung heating in the lung cancer must be likely considered. But whets the lung is heated, the esophageal temperature is higher than lung parenchyme, so the mediastinum damage must be considered seriously.