Influence of endotoxin induced fever on the pharmacokinetics of intramuscularly administered cefepime in rabbits
Journal of Veterinary Science
;
: 151-155, 2006.
Article
in English
| WPRIM
| ID: wpr-91385
ABSTRACT
This study examined the effect of experimentally induced fever on the pharmacokinetics of cefepime (75 mg/kg BW) administered intramuscularly to six rabbits. The study was carried out in two consecutive phases separated by a two-week washout period. An infection was induced by an intravenous inoculation of 5 x 10(8) colony-forming units of Escherichia coli 24 h before the pharmacokinetic investigation. A quantitative microbiological assay was employed to measure the plasma cefepime concentrations using an agar-gel diffusion method with Bacillus subtilis ATCC 6633 as the test organism. Twenty-four hour after the injection, the rectal temperature in the infected animals increased by 1degrees C. There was a significant reduction in the elimination halflife by 21.8% in the febrile rabbits compared to healthy animals. In addition, the infection significantly increased the peak plasma concentrations by 11.9%, the mean residence time by 19.9%, the area under the plasmaconcentration- time curve by 53.6% and the area under the moment curve by 62.3%. In conclusion, the endotoxin-induced febrile state produced significant changes in the plasma levels as well as some of the pharmacokinetic variables of cefepime in rabbits.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cephalosporins
/
Area Under Curve
/
Endotoxins
/
Escherichia coli Infections
/
Fever
/
Half-Life
/
Injections, Intramuscular
/
Anti-Bacterial Agents
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2006
Type:
Article
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