Relationship between Handgrip Strength and Low-grade Inflammation in Older Adults with Depression
Clinical Psychopharmacology and Neuroscience
;
: 721-730, 2021.
Article
in English
| WPRIM
| ID: wpr-914070
ABSTRACT
Objective@#The relationship among physical functional decline, low-grade inflammation, and depression remains unclear. The aim of this study was to examine the association between hand grip strength (HGS) and high-sensitivity C-reactive protein (hs-CRP) in a large sample with depression. @*Methods@#This study used data obtained from a representative Korean sample of 9,402 people who participated in the seventh Korean National Health and Nutrition Examination Survey. Physical function was assessed using a digital grip strength dynamometer. Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as ≥ 3.0 mg/L. @*Results@#In older adults (≥ 60 years) with depression, 43.8% of those with high hs-CRP levels had low HGS, compared to 21.8% of those with hs-CRP levels < 3.0 mg/L (p = 0.002). Multivariate analysis revealed that, after adjustments for potentially confounding factors, high hs-CRP was independently associated with lower HGS (B = −2.25; 95% confidence interval = −4.49 to −0.02) in older adults with depression, but not in younger or middle-aged adults with depression. @*Conclusion@#These findings suggest a significant correlation between physical functional decline and low-grade inflammation in older adults with depression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2021
Type:
Article
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