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Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression
Journal of Cancer Prevention ; : 237-243, 2021.
Article in English | WPRIM | ID: wpr-914845
ABSTRACT
Branched-chain amino acids (BCAAs), isoleucine, leucine and valine, are essential amino acids with vital roles in protein synthesis and energy production. We reviewed the fundamentals of BCAA metabolism in advanced cancer patients. BCAAs and various catabolic products act as signalling molecules, which activate mechanisms ranging from protein synthesis to insulin secretion. Recently, BCAA metabolism has been suggested to contribute to cancer progression. Of particular interest is the modulation of the mTOR activity by BCAAs. There are likely multiple pathways involved in BCAA metabolism implicated in carcinogenesis. Understanding the mechanism(s) underlying altered BCAAs metabolism will significantly advance the current understanding of nutrient involvement in carcinogenesis and direct future studies to unravel the significance of BCCA metabolites in tumor development and progression.
Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Journal of Cancer Prevention Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Journal of Cancer Prevention Year: 2021 Type: Article