The Effect of Lung Volume on the Size and Volume of Pulmonary Subsolid Nodules on CT: Intraindividual Comparison between Total Lung Capacity and Tidal Volume

ABSTRACT

Purpose@#To examine the effect of lung volume on the size and volume of pulmonary subsolid nodules (SSNs) measured on CT. @*Materials and Methods@#A total of 42 SSNs from 31 patients were included. CT examination was first performed at total lung capacity (TLC), and a section containing the nodule was additionally scanned at tidal volume (TV). The diameter and volume of each SSN, as well as the crosssectional lung area containing the nodule, were measured. The significance of the changes in measurements between TLC and TV within the same individuals was evaluated. @*Results@#The lung area and the diameter and volume of SSNs decreased significantly at TV by 12.7 cm2 , 0.5 mm, and 46.4 mm3 on average, respectively (p < 0.001), compared to those at TLC. Changes in lung area between TV and TLC were positively correlated with the change in SSN diameter (p = 0.027) and volume (p = 0.014). However, after correction (by considering the change in lung area), the changes in SSN diameter (p = 0.124) and volume (p = 0.062) were not significantly different. @*Conclusion@#SSN size and volume can be significantly affected by lung volume during CT scans of the same individuals.