The role of nuclear factor I-C in tooth and bone development
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 63-69, 2017.
Article
in English
| WPRIM
| ID: wpr-91687
ABSTRACT
Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic(-/-) mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Osteogenesis
/
Osteoporosis
/
Tooth
/
Bone Development
/
Dentinogenesis
/
NFI Transcription Factors
/
Mesenchymal Stem Cells
/
Odontoblasts
Limits:
Animals
Language:
English
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2017
Type:
Article
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