Recent Perspective on Thiazolidinedione / 임상당뇨병

ABSTRACT

Thiazolidinedione (TZD) is an insulin sensitizer that improves insulin resistance in the adipose tissue, liver, and muscles and has a pancreas-protective effect while inhibiting gluconeogenesis. Its other advantages include a glucose lowering effect, its durability, cardiovascular benefit, and recent evidence in nonalcoholic fatty liver disease and dementia. However, there are also concerns about fluid retention/edema/heart failure, bladder cancer, and fractures with TZD use. TZD can still be a useful option for diabetes treatment when calculating risk versus benefit, but appropriate selection of patients is needed.