Improvement of synthetic route of brivudine / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 41-45, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-920648
ABSTRACT
@#This article summarizes and analyzes the reported synthetic routes of brivudine in patent and literature.2′-Deoxyuridine was employed as starting material, affording brivudine through iodization, heck coupling, hydrolysis, decarboxylation, bromination and recrystallization.After optimization of reaction conditions of each step, a synthetic route suitable for industrial production was achieved with simple synthetic process, high yield and excellent purity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2022
Type:
Article
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